gene-modified 32d cell lines Search Results


gene-modified 32d cell lines  (clea japan inc)
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clea japan inc gene-modified 32d cell lines
iPAI-1 protects chronic myeloid leukemia cells from tyrosine kinase inhibitor treatment. (A) A representative flow cytometric profile for intracellular plasminogen activator inhibitor-1 (iPAI-1) expressions in PAI-1-overexpression (PAI-1 OE), PAI-1-knockdown (PAI-1 KD), or wild-type parental <t>32D</t> p210 cells (PAI-1 WT). (B) Representative flow cytometric profiles and percentage of Annexin V + /PI + population in PAI-1 OE, PAI-1 KD, or PAI-1 WT cells before imatinib (Pre-IM) and after imatinib (Post-IM) treatment in vitro (n=6). (C) Schema for in vivo experiments. (D) Representative flow cytometric profiles and percentages of leukemic cells in the bone marrow (BM) (n=7). Data represent means ± standard deviation. Statistical significance was determined by Mann-Whitney unpaired t -test. P <0.001, by a Kruskal-Wallis test. GFP: green fluorescent protein.
Gene Modified 32d Cell Lines, supplied by clea japan inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
gene-modified 32d cell lines - by Bioz Stars, 2026-09
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iPAI-1 protects chronic myeloid leukemia cells from tyrosine kinase inhibitor treatment. (A) A representative flow cytometric profile for intracellular plasminogen activator inhibitor-1 (iPAI-1) expressions in PAI-1-overexpression (PAI-1 OE), PAI-1-knockdown (PAI-1 KD), or wild-type parental 32D p210 cells (PAI-1 WT). (B) Representative flow cytometric profiles and percentage of Annexin V + /PI + population in PAI-1 OE, PAI-1 KD, or PAI-1 WT cells before imatinib (Pre-IM) and after imatinib (Post-IM) treatment in vitro (n=6). (C) Schema for in vivo experiments. (D) Representative flow cytometric profiles and percentages of leukemic cells in the bone marrow (BM) (n=7). Data represent means ± standard deviation. Statistical significance was determined by Mann-Whitney unpaired t -test. P <0.001, by a Kruskal-Wallis test. GFP: green fluorescent protein.

Journal: Haematologica

Article Title: Targeting of plasminogen activator inhibitor-1 activity promotes elimination of chronic myeloid leukemia stem cells

doi: 10.3324/haematol.2019.230227

Figure Lengend Snippet: iPAI-1 protects chronic myeloid leukemia cells from tyrosine kinase inhibitor treatment. (A) A representative flow cytometric profile for intracellular plasminogen activator inhibitor-1 (iPAI-1) expressions in PAI-1-overexpression (PAI-1 OE), PAI-1-knockdown (PAI-1 KD), or wild-type parental 32D p210 cells (PAI-1 WT). (B) Representative flow cytometric profiles and percentage of Annexin V + /PI + population in PAI-1 OE, PAI-1 KD, or PAI-1 WT cells before imatinib (Pre-IM) and after imatinib (Post-IM) treatment in vitro (n=6). (C) Schema for in vivo experiments. (D) Representative flow cytometric profiles and percentages of leukemic cells in the bone marrow (BM) (n=7). Data represent means ± standard deviation. Statistical significance was determined by Mann-Whitney unpaired t -test. P <0.001, by a Kruskal-Wallis test. GFP: green fluorescent protein.

Article Snippet: Another set of experiments, gene-modified 32D cell lines were also transplanted into non-irradiated C3H/HeNCrl mice (CLEA Japan).

Techniques: Over Expression, In Vitro, In Vivo, Standard Deviation, MANN-WHITNEY